This chapter explores the complicated relationships between feminist gerontology, religion, and gender roles, specifically within the complicated framework of HIV and AIDS in Botswana. By carrying out an extensive literature review, the research amalgamates findings from prior studies regarding elderly caregiving in the framework of HIV and AIDS, with an emphasis on the socio-cultural and religio-cultural elements that influence these experiences. In the conventional Setswana cultural setting, caregiving tasks are mainly designated to women, whereas men often take on the duties of provider, protector, and enforcer of discipline. This inquiry grounded in literature systematically explores the ways in which these deeply embedded socio-cultural gender norms contribute to ongoing systemic oppression of older women in Botswana. Utilizing the perspectives of feminist gerontology alongside religious paradigms, the chapter examines the domestic socio-cultural perceptions that worsen the vulnerable status of older women during the HIV and AIDS period. Additionally, it broadens its reach beyond the scope of the pandemic, employing theoretical models aimed at advocating for the lasting health and well-being of older caregivers. By adding to the intricate comprehension of the obstacles encountered by older women amid HIV and AIDS circumstances, this chapter participates in the gradual reconfiguration of dominant gender norms, thereby encouraging a more nurturing setting for older women. This endeavor corresponds with the wider objectives of the African Union’s Agenda 2063, which seeks to advocate for a flourishing Africa anchored in inclusive growth and sustainable development.