Chronic infections have common complications for both mothers and fetuses. Those complications may happen during early pregnancy period and/or during late period and even during labor. The viral infections counted the majority of these infections. To differentiate variable etiology of this infection should start with careful history taking, routine maternal serology assessment, and workup of fetal anomalies and early detection by ultrasound, assess maternal status and proper physical examination, and measurement of viral load and other laboratory parameters, one of the important steps that to assess the safety and effectiveness of antiviral medications. Moreover, when the maternal infection is already known, preconception counseling and pregnancy planning at a time of food clinical and therapeutic compensation would be Ideal.