Pregnancy-related complications are still a real health problem worldwide, with obvious differences associated with local demographic, political, and socio-economic features. Needed strategies and actions to promote healthy pregnancy are complex, due to this heterogeneity. Anyway, international and national health organizations continually work to develop new series of recommendations with updated and strong scientific evidence. Alongside scientific considerations however, comprehensiveness, contextualization and individualization of health programs, communication, and education are the basis of action to promote and offer the best antenatal care.