The IVF laboratory has attracted numerous new technologies and automation approaches. The technological advances discussed in the present chapter include time-lapse technology (TLT), artificial intelligence (AI) with computer vision for embryo selection, microfluidics for sperm selection, oocyte denudation and embryo culture, computer-assisted sperm analysis (CASA), robotic ICSI, automated vitrification, electronic witnessing systems, and continuous monitoring of clinic conditions. Importantly, the implementation of new products, methods, and interventions in routine clinical practice must be accompanied by sufficient evidence that verifies the efficacy and safety of a given procedure [1, 2]. However, a clear increase in IVF success rates with the use of these technologies remains to be proven.