This Chapter is the first of the analyzing chapters of the proposals found within One Health approaches in Chaps. 2 and 3 . Main emphasis of this chapter is suggestions of ethical frameworks originating from an anthropocentric view. After a brief introduction where I discuss the importance of agreeing on human rights, I will give an overview of anthropocentric bioethics. Thereafter, I analyze the two suggestions being made within One Health approaches, Principlism and Biophilia. Principlism, by Tom L. Beauchamp and James F. Childress, is an ethical framework that claims that regardless of ethical conviction, one can adopt the use of four ethical principles that will guide ethical decisions in the healthcare sector. Biophilia is a framework proposed by Edward O. Wilson and further developed by Stephen R. Kellert, which has its origin in ecology and describers values that humans have in relation to nature. Both these are dismissed due to the problem of not being inclusive enough for One Health approaches. They also violate the claim that One Health approaches need to consider humans, animals, plants, and ecosystems.