Glucocorticoid injections are frequently used to treat acute and chronic laryngeal inflammatory disorders. With the advances in technology and the introduction of a flexible endoscope with a working channel, laryngeal steroid injections are now easily performed in an office setting under local anesthesia. Their span of application has expanded to include the treatment of laryngeal scarring, infectious diseases, autoimmune disorders, and many exudative lesions of the lamina propria. Intralesional steroid injection (ILSI) has became an effective alternative to microlaryngeal surgery in the management of many voice disorders. If successfully performed, ILSI may obviate the need for surgical intervention in the operating room—thus sparing the patient the risks of general anesthesia and the morbidity of suspension microlaryngoscopy. In patients with vocal fold fibrosis, scars, and benign lesions of the vocal folds, the injection is usually made in the superficial layer of the lamina propria. The corticosteroid solution is typically injected into Reinke’s space—and a bleb formation following the injection is considered by many laryngologists as a sign of a good injection. In many instances, more than one injection is needed to accomplish the desired effect.