Total knee arthroplasty (TKA) is a commonly performed procedure to treat end-stage osteoarthritis. The knee joint is supplied by a combination of femoral nerve, sciatic and obturator nerves. Various anesthetic approaches like general anesthesia, central neuraxial block (epidural or spinal) and/or peripheral nerve blocks have been described for TKA. Regional analgesia reduces pain scores, opioid requirement and overall adverse effects. A combination of regional blocks results in better pain management and lower side effects. However, some techniques result in motor weakness which can delay recovery. Adductor canal block provides good analgesia with minimal affect on muscular strength and facilitates early recovery. Novel regional analgesia techniques like infiltration between the popliteal artery and capsule of knee (iPACK) block have also been used effectively. We have described various multimodal analgesia options in patients undergoing TKR and cruciate ligament surgery under anesthesia.