Depression is a significant mental health concern among children and adolescents, with increasing prevalence in recent years. It is commonly treated using cognitive-behavioral therapy (CBT), an evidence-based treatment that addresses maladaptive thought patterns and avoidance behaviors. While the positive impact of CBT has been extensively studied in depressed children and adolescents, its application to Jewish youth has been less discussed and requires cultural sensitivity and adaptations. This chapter explores cognitive and behavioral mechanisms underlying depression, emphasizing the impact of religious identity, communal expectations, and life-cycle events such as the bar/bat mitzvah. It examines how Jewish traditions, gender roles, and community structures can act as both protective and risk factors for depression, and discusses the role of religious leaders, Jewish education, and youth organizations in shaping mental health outcomes. Explanations for how to adapt strategies such as behavioral activation and cognitive restructuring to address challenges unique to Jewish youth are also discussed, and case studies are used to illustrate how therapists can help clients navigate family conflicts, self-perception, and community expectations. By adopting a culturally competent approach, clinicians can enhance treatment effectiveness and support Jewish youth in integrating their mental health with their cultural and religious identity.