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During embryonic eye development, mTOR signaling integrates metabolic, growth, and differentiation cues from PI3K/AKT, Wnt/β-catenin, Notch, and HIF-1α/VEGF, and other pathways, to ensure proper retinal progenitor proliferation, RPE formation, neurogenesis, and vascular development. Disruptions in these interactions can result in congenital ocular malformations such as microphthalmia, coloboma, retinal dysplasia, and optic nerve hypoplasia. Understanding these mechanisms provides insights into early-onset retinal diseases and potential therapeutic targets for congenital eye disorders.

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mTOR Effect on Eye Embryology

  • 章节

  • 发表日期：

    2025年

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  • Kambiz Thomas Moazed

摘要

During embryonic eye development, mTOR signaling integrates metabolic, growth, and differentiation cues from PI3K/AKT, Wnt/β-catenin, Notch, and HIF-1α/VEGF, and other pathways, to ensure proper retinal progenitor proliferation, RPE formation, neurogenesis, and vascular development. Disruptions in these interactions can result in congenital ocular malformations such as microphthalmia, coloboma, retinal dysplasia, and optic nerve hypoplasia. Understanding these mechanisms provides insights into early-onset retinal diseases and potential therapeutic targets for congenital eye disorders.