Despite recent advances in understanding, modelling and forecasting natural hazards and their impact on communities, infrastructure and livelihoods, such events may still cause high economic, environmental and human losses. In recent years, there have been many natural disasters in the world that have caused damage to society and infrastructure. In addition, climate change is expected to lead to more extreme weather phenomena, such as longer and more intense heat waves, more torrential rains, and stronger winds triggering several fires and probably causing many deaths in excess due to extreme temperatures. In this light, the aim of this work is to assess cascading impact by considering the multiple natural hazards involved through a resilient, service-oriented and people-centred approach. This includes identifying possible interdependencies on sectoral goods and infrastructure in particular transport, energy and water as well as on supply chains and networks. Innovative methodology will be developed within a comprehensive European project named “Multi-risk and risk-informed system for better local and regional disaster risk management (MEDiate)” which aims to develop a decision support system (DSS) for disaster risk management. Thanks to its scalability and replicability it will be applied in different contexts taking into account different hazard for different asset.