Establishing better system connectivity by linking disparate legacy systems and information silos across Europe has been at the center of research the past years. Concepts like service federation, interoperable logistics, data spaces and system unification highlight the significance of unifying systems and data by promoting system interoperability and compatibility. Although promising, these are still at conceptual level, while limited practical evidence has been provided at the moment. FENIX Federated Network established the first pan-European federated network of interoperable platforms as an enabler of B2B and B2A data exchange and sharing between transport and logistics platforms in Europe. Using the Operational Evaluation Measurement Framework, this paper measures the impact of FENIX Federated Network, used as enabler for end-to-end supply chain digitalization, to the operational performance of selected logistics operations across Europe. Notable outcomes include higher load factors, increase in modal shift for both road and rail operations, increase in delivery reliability, enhancement of the digitalization processes (digital document exchange, process automation), as well as important decreases in the operational externalities (CO2, NOx emissions) and the related process times (i.e., fulfillment, customs, turnaround, (un)loading, administration, automation, travel).