This paper contains case studies that help demonstrate the digital twins we have developed and their benefits. Several practical applications of digital twins for high-tech enterprises and infrastructure objects are introduced. Firstly, proposed digital model for analyzing the processes of controlling the flow of semi-finished products and calculating the characteristics of nanoelectronic production. This model is used to make decisions about the management of semi-finished products flows in multicluster technological complexes of any architecture, taking into account resource limitations and risk factors. Secondly, a simulation model of energy consumption at the metallurgical enterprise, which covers the entire metal products manufacture process, has been also developed. As a result of modeling, it was possible to increase the productivity of electric arc furnaces and ladle furnaces and reduce the maximum consumption of active power by the metallurgical enterprise. The third application is related to the creation of an adaptive intelligent system, for monitoring and controlling the technological process for electrochemical corrosion protection of main pipelines. The system provides remote control of electrochemical protection parameters and their optimization, as well as adaptive control of the parameters of cathodic protection stations while taking into account changes in external conditions. Two examples of simulation modeling of infrastructure objects of the street and road network and construction are considered.