HBIM technologies demonstrate increased potential in managing existing built heritage, leading to improved building lifecycle engineering. However, applying HBIM protocols to Cultural Heritage, particularly museum assets, represents an outstanding question. The study provides the findings of a research project done at the Galleria Borghese Museum to implement a geometric and informative BIM-based digital environment for museum management, as well as preventive and predictive maintenance. Furthermore, the study examines, referring to the debate over the widespread application of integrated digital technologies to cultural heritage management, the opportunities and challenges associated with digitization processes towards the goal of the implementation of Digital Twin (DT) (Vuoto in Int. J. Arch. Herit. 18(11), 1762–1795, 2024) and Digital Cultural Objects (DCO), as well as the transferability of the study’s findings. The Galleria Borghese Museum provides the scholar with the opportunity to examine architectural and artworks integrated into the form of places of both permanent and temporary exhibitions, multidisciplinary study areas, spaces of restoration of art and architecture, and places conceived for the valorization, communication, and participation of a large public of experts and non-experts.