6D Building Information Modeling (BIM) enhances energy-efficient design by integrating advanced energy analysis into building models. This study employs TerMus PLUS, a 6D BIM tool, to assess energy consumption in a typical 2-storey residential house in Hanoi, northern Vietnam. In more detail, a parametric study examines the impact of key design parameters, including exterior and interior wall materials and thickness, painting color, window type, and window area, on the building’s energy performance. Using Hanoi’s hot-humid climate data, energy simulations were conducted to compare various design configurations. The results identify painting color, window type and window area as the most influential factors in reducing energy consumption. The findings offer practical recommendations for optimizing residential designs in Vietnam’s tropical climate. This study highlights the potential of 6D BIM tools like TerMus PLUS to support sustainable design, providing architects and engineers with accurate forecasts of building energy consumption, thereby providing optimal design options.