This chapter explores the complex ethical and philosophical dimensions of AI communication as machines increasingly participate in human dialogue, decision-making, and meaning-making. It examines the evolving human–AI relationship, emphasising the importance of trust, boundaries, and healthy dependencies. Key ethical challenges in AI-human collaboration are analysed, including agency erosion, bias amplification, and transparency deficits. The chapter further addresses regulatory needs, proposing frameworks grounded in rights, responsibilities, and professional communication ethics. It interrogates the provocative issues of artificial subjectivity and consciousness, clarifying the distinction between simulated and genuine agency, while exploring the risks of deceptive anthropomorphism. Questions of AI identity, agency, and potential personhood are considered in the light of transparency, proportionality, and human primacy. Finally, the chapter reflects on how AI systems influence human meaning-making, creativity, and cultural narratives, and calls for value-aligned, culturally pluralistic design. Together, these discussions present a roadmap for ethically navigating an AI-mediated communicative future grounded in responsibility, justice, and human dignity.