Gender-based violence is an enduring issue that impacts individuals across many age groups, racial and socioeconomic identities in the Global South. Promoting gender equality and healthy relationships are some of the best strategies to prevent gender-based violence. An environment of respect and support is created when everyone is treated equally, regardless of gender. The focus of this chapter is on the promotion gender equality and healthy relationships. It starts by discussing the link between gender inequality and gender-based violence, and the importance of promoting gender equality as a primary prevention strategy. The chapter then discusses the role of health communication in gender-based violence prevention, and the role of health communication in promoting healthy relationships, consent, and mutual respect to prevent gender-based violence. The chapter also discusses examples of successful partnerships and coalitions that have made a significant impact on health communication programmes for the prevention of gender-based violence in some Global South countries.