The advent of green-synthesized nanomaterials has revolutionized post-harvest practices, offering innovative solutions in food preservation and packaging. These nanomaterials, derived from eco-friendly sources, present a sustainable alternative to conventional methods, significantly extending the shelf life of perishable goods. Their unique properties, such as antimicrobial activity, enhanced barrier performance, and controlled release mechanisms, make them ideal candidates for food preservation. In packaging, green nanomaterials contribute to the development of active and intelligent packaging systems, which can monitor food quality, prevent contamination, and reduce spoilage. This chapter explores the applications of green-synthesized nanomaterials in the post-harvest phase, focusing on their role in enhancing food safety, quality, and shelf life. Through case studies and practical applications, this chapter highlights successful implementations of these nanomaterials across various sectors, demonstrating their potential to transform the food industry. Emphasis is placed on the economic and environmental benefits of adopting these green technologies, including reduced food waste, lower reliance on synthetic chemicals, and minimized environmental impact. The review also addresses the challenges associated with the large-scale application of green nanomaterials, such as regulatory hurdles, consumer acceptance, and scalability issues. Overall, this chapter underscores the promise of green-synthesized nanomaterials as a pivotal tool in modernizing post-harvest practices, paving the way for a more sustainable and efficient food supply chain.