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The origins of veterinary radiation oncology are deeply tied to comparative radiobiology studies and animal models of normal tissue tolerances. In this chapter, we will provide a brief background on the biologic effects of ionizing radiation with a focus on the role of comparative radiobiology in terms of normal tissue tolerances, investigations into radiobiologic principles such as the DNA damage response, hypoxia, and hyperthermia, and the role of companion animal models in clinical radiation oncology.

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Comparative Radiobiology and Radiation Therapy

  • 章节

  • 发表日期：

    2026年

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  • Charles A. Maitz,
  • Ravi Patel

摘要

The origins of veterinary radiation oncology are deeply tied to comparative radiobiology studies and animal models of normal tissue tolerances. In this chapter, we will provide a brief background on the biologic effects of ionizing radiation with a focus on the role of comparative radiobiology in terms of normal tissue tolerances, investigations into radiobiologic principles such as the DNA damage response, hypoxia, and hyperthermia, and the role of companion animal models in clinical radiation oncology.