This chapter focuses on the study of flotation treatment combined with biological treatment for wastewater management. Flotation processes are increasingly recognized for their efficiency in separating suspended solids and oils from wastewater, making them particularly suitable for food processing and petroleum industries. Integrating flotation with biological treatment methods, such as activated sludge or biofilm reactors, enhances the removal efficiency of organic pollutants and nutrients. This chapter discusses the mechanisms of flotation, the types of flotation systems, and their operational parameters. Furthermore, it explores the synergistic effects of combining flotation with biological treatment, presenting case studies demonstrating improved treatment performance. The findings highlight the potential of this combined approach for achieving higher treatment standards and compliance with environmental regulations.