This chapter establishes the theoretical foundation for understanding destination dynamics, particularly in the MICE sector. It thoroughly explores Stakeholder Theory (ST), defining stakeholders as any group or individual who can affect or is affected by an organization’s objectives. The chapter examines ST’s normative, descriptive and instrumental dimensions, highlighting its role in blending business and ethics by emphasizing value creation for all stakeholders. It delves into stakeholder analysis (identification, stakes, salience based on power, legitimacy and urgency) and stakeholder synthesis (strategic management balancing economic and ethical considerations). Furthermore, it discusses networking and systemic logic, defining a tourist destination as a complex product shaped by coordinated efforts. The “6 A’s” model (Access, Attractions, Accommodation, Amenities, Ancillary services, Assemblage) is introduced as a framework for destination analysis. Different network configurations, shared governance, lead organization and network administrative forms are presented as crucial for effective territorial management.