This chapter introduces the critical theme of governance and its evolution in the tourism sector, with a specific focus on destination governance for conference destinations. It highlights how an effective territorial governance policy can provide a competitive advantage in the increasingly globalized and competitive tourism market, where competition occurs between territorial systems rather than individual companies. The MICE (Meetings, Incentives, Congresses and Events) industry is central to this analysis, given its significant economic impact and the need for adequate infrastructure and coordinated action. The chapter outlines the methodology and the research objectives. It underscores the importance of a managerial approach to coordinate and integrate offerings within a strategic systemic framework.