Numerous disruptions occur regularly in power systems, which can result in various power system defects. Power loss is a serious problem that lowers the effectiveness of electrical machinery, tampers with system stability and quality, and affects revenue and customer satisfaction. A precise reduction in loss is essential for the effective power transfer and distribution of electricity. The power loss in transmission systems is the main topic of this study. The Unified Power Flow Controller is chosen as the solution because of its adaptability and capacity to control a range of power system parameters, including active power, line impedance, bus voltage, reactive power, and load angle. In this chapter, MATLAB/Simulink software is applied for modeling and conducting the simulation, which encompasses the northwest region power system network and the unified power flow controller (UPFC). The transmission line’s power loss under steady-state conditions is calculated to be 2.048 MW. Nevertheless, the loss is decreased to 85.12 kW when the UPFC is linked to the power system network, saving 1.69 MW of electricity. The loss increases to 2.0482 MW when the power system network is subjected to a three-phase fault at the 230 kV distribution network that is sustained for 0.1–0.5 seconds. Using the UPFC saves at least 1.963 MW of power that would have been lost in the transmission line by reducing the power loss to 82.21 kW.