Neurostimulation constitutes a valid management option for patients with drug-resistant epilepsy (DRE), who are not candidates for resective procedures. Peripheral, deep brain, and cortical responsive stimulations are available. The stimulation may be delivered in an open- or closed-loop fashion. The underlying mechanisms of action for both modalities are briefly discussed, and their advantages and disadvantages are reviewed. The future perspectives of neurostimulation are also explored.