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While patients with drug-resistant primary generalized seizures are not eligible for resective surgery, they may benefit from a neuromodulation treatment targeted to the thalamic centromedian nucleus, more specifically, its parvocellular, ventrolateral part. Neurophysiological verification of the electrode positions during implantation turns out to be the best predictor for seizure reduction, which may range from 50% to 100%. After battery depletion, seizure control regularly outlasts stimulation for several months. In patients with catastrophic epilepsy and limited economic resources or in very young children, radiofrequency lesions in the parvocellular part of the centromedian nucleus also proved to be beneficial.

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The Centromedian Thalamic Nucleus as a Deep Brain Stimulation Target in the Management of Epilepsy

  • 章节

  • 发表日期：

    2026年

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  • Francisco Velasco,
  • Ana Luísa Velasco,
  • Pablo Saucedo,
  • José Luís Navarro,
  • Manola Cuellar,
  • David Trejo,
  • Stephani Heres,
  • Gustavo Aguado

摘要

While patients with drug-resistant primary generalized seizures are not eligible for resective surgery, they may benefit from a neuromodulation treatment targeted to the thalamic centromedian nucleus, more specifically, its parvocellular, ventrolateral part. Neurophysiological verification of the electrode positions during implantation turns out to be the best predictor for seizure reduction, which may range from 50% to 100%. After battery depletion, seizure control regularly outlasts stimulation for several months. In patients with catastrophic epilepsy and limited economic resources or in very young children, radiofrequency lesions in the parvocellular part of the centromedian nucleus also proved to be beneficial.