Alleviation of epileptic drop attacks is perhaps the most important goal of any antiseizure treatment. Because sudden falls due to tonic or atonic ictal phenomena lead to recurrent bruises and fractures, these seizures preclude the patient and the family from an independent life, so their control is a medical imperative. Unfortunately, because recurrent atonic and tonic seizures are most often seen in patients with diffuse brain disorders associated with high degrees of epileptogenicity, antiseizure medication (ASM) almost never fully controls these attacks. Based upon the assumption that at ictal onset, a sudden bilateral synchronization of epileptic discharges through the corpus callosum is the necessary electric phenomenon for a fast-spreading polysynaptic cascade that leads to falls, corpus callosotomy (CC) has historically been proposed as a “palliative” surgical strategy to mitigate the risk of drop attacks. In this chapter, we show that, in contrast to traditional anatomical views, fibers from the premotor and motor cortex synchronize their activity by crossing through the posterior body and isthmus of the corpus callosum. Thus, sectioning the posterior half of the corpus callosum is an anatomical imperative to control synchronization of epileptic activity from these motor regions. It explains why patients undergoing varying degrees of anterior callosotomy often fail to have significant control of drop attacks. We further show that selective division of the posterior corpus callosum achieves the goal of controlling drop attacks to a very similar degree as complete callosotomy (CC), while preserving prefrontal interconnectivity, which is advantageous for cognition. Moreover, and in line with the above assumption regarding the pathogenesis of drop attacks, very favorable results with selective posterior callosotomies are obtained, irrespective of the underlying etiology. Finally, because what matters to control drop attacks is preventing bilateral synchronization of epileptic discharges from motor and premotor regions through the posterior callosum, remaining bilateral synchronous discharges on the EEG, likely originating from prefrontal regions, do not influence the surgical outcome.