This chapter provides an overview of the surgical techniques and pitfalls of complete corpus callosotomy (CCC), including laser ablation and endoscopic techniques. The history, patient selection, indications, and outcome of CCC are briefly presented. A step-by-step description of the microneurosurgical approach to CCC is presented and illustrated by figures and two videos. Frequent, drug-resistant seizures with early generalization and atonic seizures (drop attacks), together with intellectual disability, are common in patients considered for CCC. Relevant anatomical landmarks for CCC include the pericallosal arteries, the rostrum, and the splenium. A one-stage CCC can be safely achieved by proper planning of the procedure and careful dissection of the interhemispheric fissure. CCC is a safe and effective procedure with a very high likelihood of controlling drop attacks.