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Epileptogenic multiple and deep-seated lesions like tubers in tuberous sclerosis (TSC) pose a great challenge for resective epilepsy surgery. Laser interstitial thermal therapy (LITT) offers a minimally invasive targeting and ablation method for focal epileptogenic lesions. Thus, TSC patients may benefit from multiple minimally invasive ablations to control seizures at least temporarily. We developed a strategy using SEEG and intraoperative MRI to apply LITT in single or multiple tubers. We found a response rate of at least 50% with epilepsy-free intervals averaging 3–6 months up to 1 year. LITT for the ablation of tubers in TSC patients proved to be feasible and effective without severe complications.

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LITT Ablation for Subcortical Epileptogenic Lesions

  • 章节

  • 发表日期：

    2026年

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  • Karl Roessler,
  • Martha Feucht

摘要

Epileptogenic multiple and deep-seated lesions like tubers in tuberous sclerosis (TSC) pose a great challenge for resective epilepsy surgery. Laser interstitial thermal therapy (LITT) offers a minimally invasive targeting and ablation method for focal epileptogenic lesions. Thus, TSC patients may benefit from multiple minimally invasive ablations to control seizures at least temporarily. We developed a strategy using SEEG and intraoperative MRI to apply LITT in single or multiple tubers. We found a response rate of at least 50% with epilepsy-free intervals averaging 3–6 months up to 1 year. LITT for the ablation of tubers in TSC patients proved to be feasible and effective without severe complications.