Reinforced concrete (RC) buildings on sloping terrain face significant seismic challenges due to irregular force distribution and shorter columns experiencing excessive forces. While the seismic performance of buildings with shear walls is well studied, the effect of staggered openings in shear walls remains relatively unexplored. This study investigates the seismic behavior of a 10-storey RC building on sloping terrain with staggered shear wall openings, using ETABS for analysis for both Equivalent Static Analysis (ESA) and Time History Analysis (THA). Openings were varied in width and depth while maintaining a constant area. Equivalent static analysis and dynamic analysis were performed to evaluate key seismic parameters such as lateral displacement, drift, and base shear. The results indicate that while shear walls without openings offer superior seismic resistance, introducing staggered openings leads to only slight variations in seismic parameters, making them a practical choice for balancing functionality and structural performance. Findings show that wider openings reduce lateral stiffness, increasing displacement and drift, while deeper openings maintain more wall material, improving stiffness. The optimal width for openings was identified as 1200 mm, achieving a balance between minimizing seismic effects and maintaining structural integrity. This study provides valuable insights for optimizing shear wall designs in high-rise buildings on sloping terrain, ensuring both architectural flexibility and seismic resilience.