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This chapter reviews the relationship between polysialic acid (polySia), its biosynthetic enzyme ST8SIA2, and brain diseases, particularly psychiatric disorders such as schizophrenia, bipolar, and autism spectrum disorders, as well as neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. We also focus on the connection between inflammation and the polySia degradation enzyme, sialidase (neuraminidase).

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Relationship Between Regulation of Polysialic Acid Expression and Brain Diseases

  • 章节

  • 发表日期：

    2026年

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  • Masaya Hane,
  • Chikara Abe,
  • Ken Kitajima,
  • Chihiro Sato

摘要

This chapter reviews the relationship between polysialic acid (polySia), its biosynthetic enzyme ST8SIA2, and brain diseases, particularly psychiatric disorders such as schizophrenia, bipolar, and autism spectrum disorders, as well as neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. We also focus on the connection between inflammation and the polySia degradation enzyme, sialidase (neuraminidase).