Seismic analysis, which involves response of structures to earthquakes, is vital for ensuring safety, stability, and resilience of structures in earthquake-prone regions. During intense seismic events, the dynamic response of a structure is influenced not only by the behaviour of the structure but also by the properties and behaviour of the surrounding soil. Conventional structural design methods typically assume the foundation base to be fully restrained, where this assumption is unrealistic, as it neglects the flexibility introduced by the interaction between the soil and the structure. Accurate assessment of dynamic performance of RCC buildings requires appropriate modelling that accounts the interactions between the foundation, soil, and structure. Soil–structure interaction (SSI) is particularly critical under seismic excitation due to the potentially severe consequences of earthquakes. In the present work, analysis of seismic response of plan-regular structures with dampers resting on mat foundations, considering soil–structure interaction (SSI) is carried out. The influence of damper positions on the seismic performance of the structure is examined through key parameters such as lateral displacement, inter-story drift, and base shear, using SAP2000 software. The results highlighted the importance of SSI in accurately predicting structural behaviour under seismic loads, as fixed-base models (without SSI) showed lower displacement and drift compared to those incorporating SSI, while also demonstrating the effectiveness of dampers in enhancing structural resilience.