Healthcare has traditionally focused on the physical body, addressing disease and injury through diagnosis and remediation. However, these physical issues typically connect with a web of psychological, social, and economic issues that affect well-being. Moreover, studies have revealed that many lifestyle-loving people become addicted to medical technology and ultimately experience a decline in their quality of life. Hence, although Healthcare 4.0 and beyond, the emerging technology converges and connects all things and people to improve their health as a single physical entity, we should strive for more comprehensive and preventive protection of human beings that includes other aspects beyond the mere physical. Healthcare 5.0 shifts the focus of the care system from disease to personal health, well-being, and happiness, allowing for a more comprehensive and preventive approach to disease prevention and care, as demonstrated in this chapter. The shift can be implemented with an ultra-wideband Healthcare Technology 4.0 ecosystem that mixes state-of-the-art healthcare technology with real business and addresses the user as an integrated psychosocial-economic being rather than a mere physiological entity. The goal of the ecosystem is to help healthcare providers manage patients’ health, well-being, and happiness through a customizable mixture of available or future services. These services and enabling technologies can increase the patients’ willingness to live and the motivation to prevent diseases and take care of their existing conditions. That translates to the happiest and most satisfied patients are more likely to comply with their treatment and care.