This chapter examines the commonly prescribed medications used for the treatment and management of four cardiovascular disorders. The drugs reviewed include organic nitrates, calcium-channel blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and beta-adrenoceptor blocking drugs. Additionally, the four (IV) main classes of drugs used for the treatment and management of arrhythmias and the lipid lowering class of drug, statins, are discussed. These drugs are reviewed in relation to their pharmacokinetics, mechanism of action, drug–drug interactions, adverse effects and contraindications. The clinical uses of these drugs are considered in the context of the management of angina pectoris, hypertension, heart failure and arrhythmias.