Pediatric interventional radiology, which uses imaging such as ultrasound, fluoroscopy, and computed tomography to perform minimally invasive procedures in children with liver cancer, is a growing subspecialty. Interventional radiology includes thermal ablation, transarterial chemoembolization, transarterial radioembolization with yttrium-90, and lymphatic interventions. Although locoregional therapies for treatment of cancer in adults are common, they are less common in children, perhaps due to the relative rarity of cancer in children, their typically better performance status, and paucity of comorbidities. Preliminary results from small-scale studies for ablation, transarterial chemoembolization, and transarterial radioembolization with yttrium-90 used in the front-line armamentarium of curative therapy are encouraging. However, more research is required to determine the efficacy of locoregional therapy in children and to define the clinical scenarios where benefit is likely to be optimized.