Orthotopic liver transplantation (OLT) is the definitive treatment for end-stage liver disease. Advances in surgical technique have significantly reduced the complication rate. However, vascular and biliary complications still occur in up to 25–27% of cases, with arterial complications arising at a higher rate than venous complications. The management of such complications is within the purview of the interventional radiologist. Common arterial complications requiring endovascular management include hepatic artery thrombosis (HAT), hepatic artery stenosis (HAS), and hepatic artery pseudoaneurysm (HAP), which may require thrombectomy, stent placement, angioplasty, or a combination of these techniques. Postoperative venous complications, including portal venous thrombosis and hepatic venous outflow obstruction, while uncommon, are also amenable to endovascular intervention and may require advanced thrombectomy techniques. Biliary strictures are a common postoperative complication, ranging from ischemic strictures secondary to arterial complications or anastomotic strictures related to surgical technique. Such strictures may be preferentially managed by the interventional radiologist through a percutaneous approach, given anatomical challenges to endoscopic access.