Benign biliary strictures (BBS) represent a non-malignant narrowing of the bile ducts that can result from iatrogenic injury (most commonly following cholecystectomy or liver transplant), inflammation (pancreatitis, primary sclerosing cholangitis), infection (AIDS-related, recurrent pyogenic cholangitis), ischemia, autoimmune conditions (IgG4-related disease), and extrinsic compression (portal biliopathy, Mirizzi syndrome). Patients can present within weeks to months after the initial injury but can also present many years later. Common symptoms include jaundice, pain, scleral icterus, pruritus, and right upper quadrant pain. Diagnosis relies on clinical history, laboratory studies, and imaging. Ultrasound serves as an initial screening tool, while CT and MRI/MRCP offer better anatomic detail. Even with these tools, differentiating benign from malignant causes can be difficult. Percutaneous transhepatic cholangiography (PTC) can resolve biliary obstruction when endoscopic approaches fail or are unsuitable due to post-surgical anatomy. Management requires a multidisciplinary approach. Treatment choice depends on etiology, location, and other patient factors. Options include surgical reconstruction (e.g., hepaticojejunostomy), endoscopic therapies (dilation, stenting), and percutaneous interventions. Interventional radiology plays a key role in the treatment of this disease process. Current treatment approaches include serial upsizing of biliary drains and balloon dilation. Emerging treatments include biodegradable stents and cholangioscopy-assisted laser stricturotomy.

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Benign Biliary Strictures

  • Daniel L. Kirkpatrick,
  • Eunice Moon,
  • Baljendra S. Kapoor

摘要

Benign biliary strictures (BBS) represent a non-malignant narrowing of the bile ducts that can result from iatrogenic injury (most commonly following cholecystectomy or liver transplant), inflammation (pancreatitis, primary sclerosing cholangitis), infection (AIDS-related, recurrent pyogenic cholangitis), ischemia, autoimmune conditions (IgG4-related disease), and extrinsic compression (portal biliopathy, Mirizzi syndrome). Patients can present within weeks to months after the initial injury but can also present many years later. Common symptoms include jaundice, pain, scleral icterus, pruritus, and right upper quadrant pain. Diagnosis relies on clinical history, laboratory studies, and imaging. Ultrasound serves as an initial screening tool, while CT and MRI/MRCP offer better anatomic detail. Even with these tools, differentiating benign from malignant causes can be difficult. Percutaneous transhepatic cholangiography (PTC) can resolve biliary obstruction when endoscopic approaches fail or are unsuitable due to post-surgical anatomy. Management requires a multidisciplinary approach. Treatment choice depends on etiology, location, and other patient factors. Options include surgical reconstruction (e.g., hepaticojejunostomy), endoscopic therapies (dilation, stenting), and percutaneous interventions. Interventional radiology plays a key role in the treatment of this disease process. Current treatment approaches include serial upsizing of biliary drains and balloon dilation. Emerging treatments include biodegradable stents and cholangioscopy-assisted laser stricturotomy.