This book presents a comprehensive framework for improving brain health care through contextually sensitive evaluations, addressing the growing global challenge where over one in three people are affected by neurological and mental health conditions. The work explores how evaluation can serve as a bridge between problem and solution spaces, moving beyond traditional approaches to embrace integrated, person-centered care that respects individual needs and cultural contexts. The book emerged from a partnership between the Evaluation Centre for Complex Health Interventions and the Ontario Brain Institute through the Growing Expertise in Evaluation and Knowledge Translation (GEEK) program. Using realist evaluation approaches and drawing insights from Indigenous epistemologies, the research examines how community-led solutions can address asymmetries in evidence production and promote sustainable brain health outcomes. The methodology emphasizes context-mechanism-outcome configurations to understand “what works for whom under what circumstances.” Key insights from the chapter include that evaluation functions as an intervention itself, capable of promoting comprehensive care while addressing heterogeneity in patient needs. This chapter highlights the critical role of community organizations in providing sustained care and the importance of moving from territorial to integrated approaches in brain health. The book explores the role of evaluations as essential tools for creating more equitable, responsive, and effective brain health systems that enable individuals to live full, thriving lives.