Eutectic solvents (ES) have emerged as promising alternatives to conventional organic solvents for extracting phenolic compounds from plant matrices due to their low toxicity, biodegradability, and tunable properties. This chapter explores the potential of ES in enhancing the efficiency and selectivity of phenolic compound extraction, covering different subclasses, including phenolic acids, flavonoids, anthocyanins, stilbenes, tannins, and lignin. The impact of various factors such as ES composition, polarity, viscosity, and the integration of emerging technologies like microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) on extraction performance is analyzed. Recent studies indicate that ES enhances extraction efficiency and preserves the bioactivity of the extracted compounds, offering a sustainable approach for industrial applications in the food, cosmetic, and pharmaceutical sectors. Challenges such as optimizing solvent selection, ensuring extract stability, and scaling up processes for commercial viability are also discussed. The findings highlight the need for continued research to refine ES formulations and extraction methodologies to harness their potential in green chemistry and sustainable bioprocessing fully.