Deep eutectic solvents (DESs) are a new class of mixtures that differ from their clean constituent components in that they have significantly lower melting temperatures. With their many adjustable physicochemical characteristics, these materials show promise for use as low-cost “designer” solvents. A careful review of the literature reveals that the microscopic mechanisms underlying the structure–property relationships in this family of solvents are poorly understood. In this chapter, we examine the altered behavior of deep eutectic solvents (DESs) during micellization, the use of DESs to change the micellization behavior of amphiphilic molecules, and their characterization by different methods. This chapter discusses the synthesis, characterization, types, and behavior of DESs. It also deals with the various physicochemical, interfacial, thermodynamic, and mixed micellization behaviors. To clarify the next steps required to establish a fundamental framework required for a fuller understanding of DESs, this review focuses on recent research initiatives. Recent developments in DES research are discussed, significant scientific concerns are raised, and intriguing research avenues that align with the field’s progress toward prediction models and fundamental knowledge of these solvents are highlighted.