Stroke is a leading cause of disability and mortality worldwide, ranking second in India. Approximately 5.5 million people die from strokes annually in the Indian context, with prevalence increasing in the geriatric population. Beyond physical impairments, stroke affects social and emotional well-being, reducing the quality of life (QOL). The Stroke-Specific Quality of Life (SS-QOL) scale evaluates multiple domains, including mobility, mood, self-care, and social roles. This study aimed to adapt and validate the SS-QOL in Kannada (SS-QOL-K) for stroke survivors. A speech-language pathologist (SLP) translated the SS-QOL into Kannada, followed by a reverse translation by another SLP. The expert review identified five culturally inappropriate or difficult-to-understand questions, which were modified. A pilot study with ten stroke survivors confirmed the clarity of the final Kannada version of the SSQOL-K, consisting of 49 items. The questionnaire was then administered to 100 stroke survivors and 100 neurotypical Kannada speakers. Test-retest reliability was assessed within 2–14 days, yielding a Cronbach’s alpha of 0.91, indicating excellent reliability. Internal consistency was confirmed through split-half reliability (Spearman-Brown coefficient = 0.92). Discriminant validity was established by comparing scores between groups, showing significantly lower scores among stroke survivors and higher scores in neurotypical adults, confirming the SS-QOL-K’s ability to differentiate between groups. The study concluded that SS-QOL-K is a reliable and valid tool for assessing stroke-specific QOL in Kannada-speaking individuals. Its ease of administration makes it a valuable clinical tool for evaluating the impact of stroke on patients’ lives.