The railway sector has to provide a safety performance that is economically sustainable for society. To achieve this, the railway is heavily regulated, e.g., regarding interoperability, reliability, availability and safety. In many cases, these regulations share a theoretical foundation. In addition, central standards related to asset management, dependability and risk in general mainly share the same theoretical foundation. This foundation is Reliability-Centred Maintenance (RCM), which represent the latest paradigm shift in dependability and risk. However, even though RCM was introduced in 1978, the fundamentals of RCM are not still fully embraced in practice. This unwanted situation contributes to insufficient applicability and effectiveness of maintenance tasks and thereby increased costs and unwanted safety consequences. Hence, the purpose of the study presented in this paper is to describe how RCM can be applied to fulfil requirements in railway infrastructure asset management. To fulfil the purpose, a literature study was performed to illustrate how RCM is related to railway requirements and supports the application of standards related to asset management in general. In addition, the fundamentals of RCM are related to some of the railway regulations in general, and a specific railway case study in particular. Hopefully, the presented results can contribute to an implementation of the paradigm shift that RCM represents as a key enabler to improve compliance, efficiency and effectiveness within railway.