This volume explores how different types of global challenges shape public attitudes towards the European Union. The concept of polycrisis is central to the analysis: by distinguishing between event-driven crises, process-oriented threats, and recurring threat-to-crisis issues, the volume captures the differentiated political and perceptual impact of global challenges on citizens’ evaluations of the EU. Methodologically, it combines Eurobarometer data with original surveys conducted in six EU member states, offering a comparative and longitudinal perspective on how crises influence individual support for European integration. Italy is examined as a paradigmatic case, illustrating how repeated exposure to transnational shocks intersects with volatile public opinion. The volume develops a novel theoretical framework, grounded in robust empirical analysis, to interpret the role of crises and to advance a more nuanced understanding of how citizens perceive and evaluate the Union’s role in addressing cumulative, overlapping, and disruptive global challenges.