Fungal infections have become a threatening global health issue, with over 1.5 million deaths annually. Common infections such as invasive aspergillosis, Candida bloodstream infections, and cryptococcal meningitis are highly prevalent amongst the immunocompromised populations. The total global incidence of invasive fungal infections is estimated at 6.5 million, with nearly 3.8 million deaths, of which 68% are directly attributable to fungal infections. These high mortality rates are associated with substantial economic costs. Many current treatments, including amphotericin B and azoles (imidazoles, triazoles), have limitations such as side effects, drug resistance, and relapse. Therefore, there is an increasing need for alternative antifungal drugs and strategies. Medicinal plants have long been used effectively for treating fungal diseases/infections. These plants contain a variety of secondary metabolites, including alkaloids, flavonoids, saponins, terpenoids, and phenolics, which exhibit antifungal properties through membrane disruption, inhibition of cell wall synthesis, and interference with critical fungal cellular processes. Some plant essential oils contain specific phytochemicals that can degrade certain mycotoxins. Despite having significant participation in pharmacology, the usage of plant-derived antifungal compounds has been limited by poor bioavailability and slow absorption. Recent advancements in drug delivery technologies, such as phytosomes, liposomes, nanoparticles, microemulsions, and niosomes, aim to enhance the stability, solubility, and targeted delivery of these bioactive phytochemicals. These systems facilitate better absorption, sustained release, increased shelf-life, and improved therapeutic efficacy of these antifungal compounds. Additionally, transdermal drug delivery systems, such as ethosomes and transferosomes, as topical antifungal treatments, are also being used as they provide sustained release and enhanced skin penetration of the drug. This chapter highlights the potential of medicinal plants as alternative antifungal agents, with a focus on novel drug delivery systems that improve the effectiveness of plant-based antifungal drugs. This strategy is imperative in combating the rising incidence of fungal infections.