This chapter provides a comprehensive guide to medical device commercialization and sales by following a process-oriented approach. It covers essential aspects such as target market research, regulatory approval, pricing, go-to-market considerations, customer acquisition, and relationship management as well as postmarketing surveillance to ensure a successful product launch and sustainable sales development. Insights are provided on existing practices as well as expected changes that are being driven by new technologies like artificial intelligence and predictive data analytics. All subchapters highlight the critical elements, while selected aspects such as pricing, business models, and the certification process are discussed in more detail in separate chapters.