The disastrous effects of pharmaceuticals and personal care products (PPCPs) have become a growing concern for the scientific community, which is commonly found in sewage water and freshwater bodies. Despite having such low concentrations (µg/L and ng/L) in environmental media, PPCPs can cause serious adverse effects on terrestrial and aquatic eco-environments. Also, the frequent detection of PPCPs in environmental media could be understood by the incompetency of conventional wastewater treatment plants (WWTPs) in treating emerging pollutants (EPs). However, recently, researchers have opted for various other techniques such as constructed wetlands (CWs) to remove PPCPs from wastewater. These CWs have promising performance in treating these emerging contaminants (ECs). The removal in CWs depends on various design parameters (type of CWs, flow rate, inlet feeding strategies, plant species, and substrate matrix), microbial community structure in CW, wastewater load and characteristics, microclimatic conditions (redox potential, temperature, seasonal variation), etc. This chapter discusses the overall mechanism of CWs in the remediation of PPCPs belonging to different classes. Other important aspects such as the role of substrate matrix, issues of drug resistance, clogging problems, etc. in CWs are also elaborated in brief to understand the overall benefits of CWs as low-cost bioremediation tools for PPCPs.