Nowadays, lack of awareness leads people to discard apple peels and seed or waste them, but they are significant sources of various important phytochemical constituents. Common apple (Malus domestica) is the world’s most economical fruit and belongs to the family Rosaceae, which grows worldwide in all temperate zones; subtropical and tropical zones have been added recently. An incredibly healthy fruit that is appreciated all over the world, apples are the second most delectable fruit produced by trees and have been grown in Asia and Europe since ancient times. Various studies have identified apple peels and seeds as rich in various bioactive compounds, such as flavonoids, amino acids, fatty acids, quercetin, oleic acid, phenolics, vitamins, pectin, phloridzin, sugar, chlorogenic acid, cellulose, and minerals like calcium (Ca), copper (Cu), Nickel (Ni), potassium (K), cobalt (Co), magnesium (Mg), sodium (Na), and chromium (Cr). Seeds from apples could be used to produce edible oils with added value. Apple peels contain a number of important phenolics (oligomer, epicatechin, trimer, procyanidin, quercetin, glycosides, chlorogenic acid, and phloridzin 3-hydroxyphloridzin). The antioxidant properties of the polyphenols found in apple peels have been shown to improve human health and aid in the treatment of diseases by scavenging free radicals. Due to their strong nutritional and therapeutic value, they have historically been used to cure a variety of illnesses. These days, the pharmaceutical sector uses apple seeds and peels for a variety of purposes. Apple peel has shown a significant inhibitory effect on liver cancer, colon cancer, and skin disease and removes heavy metals from wastewater. This chapter will provide scientific evidence that apple peels and seeds have potential uses in the nutraceutical, pharmaceutical, and food industries. This chapter also highlights apple’s versatile role in the disease management such as cancer, cardiovascular disorders, and skin disease.