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The Zika virus (ZIKV), a mosquito-borne flavivirus, has been linked to congenital Zika syndrome (CZS), a condition characterized by severe neurological abnormalities in infants born to infected mothers, with microcephaly being the most prominent manifestation. Despite extensive research, the molecular mechanisms driving CZS-associated microcephaly remain poorly understood. In this study, we utilized genetic network analysis to unravel the complex molecular interactions underlying CZS pathogenesis. By analyzing transcriptomic data from CZS-affected and unaffected individuals, we identified distinct gene expression signatures and regulatory networks associated with neurodevelopmental processes, immune responses, and viral pathogenesis. Key genes involved in neuronal differentiation, cell cycle regulation, and innate immunity were highlighted, offering valuable insights into the interplay between host genetic factors and viral manipulation in CZS. Our findings provide a comprehensive framework for understanding the molecular basis of CZS, paving the way for the development of targeted diagnostic and therapeutic strategies against this debilitating condition.

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Genetic Network Analyses Shed Light on the Link Between Congenital Zika Syndrome and Microcephaly

  • 会议论文

  • 发表日期：

    2026年

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  • Eleni Papakonstantinou,
  • Flora Bacopoulou,
  • Dimitrios Vlachakis

摘要

The Zika virus (ZIKV), a mosquito-borne flavivirus, has been linked to congenital Zika syndrome (CZS), a condition characterized by severe neurological abnormalities in infants born to infected mothers, with microcephaly being the most prominent manifestation. Despite extensive research, the molecular mechanisms driving CZS-associated microcephaly remain poorly understood. In this study, we utilized genetic network analysis to unravel the complex molecular interactions underlying CZS pathogenesis. By analyzing transcriptomic data from CZS-affected and unaffected individuals, we identified distinct gene expression signatures and regulatory networks associated with neurodevelopmental processes, immune responses, and viral pathogenesis. Key genes involved in neuronal differentiation, cell cycle regulation, and innate immunity were highlighted, offering valuable insights into the interplay between host genetic factors and viral manipulation in CZS. Our findings provide a comprehensive framework for understanding the molecular basis of CZS, paving the way for the development of targeted diagnostic and therapeutic strategies against this debilitating condition.