Miscarriage is a naturally occurring event that can be caused by several factors, such as work-related stress. The aim of the current systematic review was to examine the association between work-related stress and miscarriage in pregnant women, and to corroborate previous findings on the subject. A systematic review was conducted using the PubMed and Scopus databases. Observational studies published in English were considered for inclusion. A total of 412 papers were identified through the database search. After removing duplicates, 302 papers were screened, and based on the inclusion and exclusion criteria, seven studies were included in the systematic review. Our results indicate that there is an increased risk of miscarriage among women with work stress. Future research in larger population samples is needed to confirm these findings.