From the colonial period to the contemporary era, Africa has continued to be the epicentre of natural resource exploitation, especially by the Global North. Recently, China has become a dominant actor in resource exploitation on the continent. Since the 2000s, the growing demand for natural resources and land in Africa by Western capitalist business interests through foreign agri-businesses has triggered the problem of land grabbing. Some of the land grabs are for food production or biofuel crops. Land grabbing has exacerbated yet another socio-developmental challenge on the continent: the natural resources curse (NRC)—this is the premise of the investigation of this chapter. Africa is hugely endowed with abundant natural resources which, when exploited and used for the benefit of Africans, could significantly improve their socio-economic conditions and livelihood. Yet, over the years, Africa has been unable to translate the huge natural resource base into meaningful benefits for the general populace. Dubbed as the natural resources curse, this inability is highly manifested in the context of land grabbing. In this chapter, I examine the problematic issue of land grabbing and illustrate from a multi-jurisdictional standpoint in Africa, how it is one of the manifestations of NRC. I argue that land grabbing exacerbates the natural resource curse, under-development, and human rights violations in Africa. The thesis is that poor regulation of land use, or governance characterised by the inability of, and the failure of, African States to set, adequate regulatory standards for the exploitation of natural resources, makes land grabbing an exacerbator of the existing curse. From this perspective, I argue that the contemporary vehicle of Western-oriented capitalist business ventures through land grabbing is an avenue to fuel the natural resources curse that makes Africa perpetually poor. This manifests in food insecurity, environmental degradation, human rights violations, and the loss of livelihoods. It is, therefore, important to consider the pursuit of governance strategies and priorities on land investments that are consistent with Africa’s developmental aspirations exemplified by the African Union, African Charter on Human and Peoples Rights, and Africa Agenda 2063.