The oral cavity is connected to systemic health, with dental pathologies often influencing and being influenced by systemic conditions. Oral diseases, such as periodontitis and dental infections, have been associated with cardiovascular disease, diabetes, and other chronic conditions, highlighting the bidirectional relationship between oral and general health. In addition, mastication plays a key role in digestion, nutrition, and neuromuscular function, while malocclusion has been associated with temporomandibular disorders, postural imbalances, and potentially even cognitive impairment. The neuraltherapeutic medicine considers clinical aspects of dental treatment go beyond symptom management, requiring a holistic approach that considers the patient’s medical history, systemic conditions, and individual physiological responses. The use of local anesthetic (procaine), when integrated into dental practice and aligned with interdisciplinary medical approaches, has demonstrated promising outcomes in patient care dentistry with other medical disciplines have shown promising results in patient care. In addition, case reports provide valuable information on the complex interaction between dental conditions and systemic diseases, offering practical evidence on diagnosis, management, and treatment efficacy. This chapter explores the interconnection between oral and systemic health, highlighting the importance of a multidisciplinary approach for improving patient outcomes.