Diagnostic practice has historically been an act of research and observation in medicine to not only identify cases of disease but also to unravel its causes. However, with the modern age, a nosographic classification system based on analysis was established, where diseases were reduced to species, assuming them as entities or things that rest on the individual. The diagnostic approach of Neuraltherapeutic medicine, in its systemic-complex current, was nourished by different sources, such as neural therapy according to Huneke, synthetic physiology, British nervism, and complexity sciences, among others. These concepts were integrated under a new perspective that states that diagnosis is a dynamic and open process, which moves away from nosographic classifications to give priority to individuality and life narratives. From this perspective, a diagnostic scheme based on pathophysiological dynamics is proposed, which presents qualitative differences according to their location, temporality, and dominant expression. Finally, the importance of considering the concept of focus or dominant center within the diagnostic practice of Neural therapeutic medicine is highlighted.